Antihistamines + Tapentadol 200 mg - Sedation Risk
Why the Risk?
Tapentadol (Tapady 200 mg): As an opioid analgesic, Tapentadol inherently causes central nervous system (CNS) depression, leading to side effects like drowsiness, dizziness, and impaired coordination.
Antihistamines:
First-generation antihistamines (e.g., diphenhydramine [Benadryl], chlorpheniramine, promethazine, doxylamine) readily cross the blood-brain barrier and cause significant sedation. They are often found in over-the-counter sleep aids, cold, and allergy medications precisely for this effect.
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